※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinases), belong to the AGC family, are characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR and regulation de downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4, and involved in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAF-00048	ENSCAFG00000011733	ADRBK1
2		EKS-CAF-00047	ENSCAFG00000011603	ADRBK2
3		EKS-CAF-00050	ENSCAFG00000007702	GRK7
4		EKS-CAF-00045	ENSCAFG00000012129	GRK5
5		EKS-CAF-00044	ENSCAFG00000016388	GRK6
6		EKS-CAF-00046	ENSCAFG00000014693	GRK4
7		EKS-CAF-00049	ENSCAFG00000006393	GRK1