※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinases), belong to the AGC family, are characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR and regulation de downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4, and involved in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAP-00046	ENSCPOG00000012872	GRK4
2		EKS-CAP-00050	ENSCPOG00000013262	GRK7
3		EKS-CAP-00049	ENSCPOG00000013493	GRK1
4		EKS-CAP-00047	ENSCPOG00000009793	ADRBK2
5		EKS-CAP-00048	ENSCPOG00000015449	ADRBK1
6		EKS-CAP-00045	ENSCPOG00000007453	GRK5
7		EKS-CAP-00044	ENSCPOG00000004047	GRK6