※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinases), belong to the AGC family, are characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR and regulation de downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4, and involved in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORL-00063	ENSORLG00000001133	ADRBK1
2		EKS-ORL-00060	ENSORLG00000001365
3		EKS-ORL-00057	ENSORLG00000012670
4		EKS-ORL-00061	ENSORLG00000012586	RHOK; Q5NUF5_ORYLA
5		EKS-ORL-00059	ENSORLG00000004724	O73659_ORYLA; Ola.76
6		EKS-ORL-00062	ENSORLG00000011609	GRK7 (1 of 2)
7		EKS-ORL-00056	ENSORLG00000014627	GRK4
8		EKS-ORL-00058	ENSORLG00000018337	GRK6