※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinases), belong to the AGC family, are characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR and regulation de downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4, and involved in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00066	ENSTRUG00000013181	GRK1 (2 of 2)
2		EKS-TAR-00063	ENSTRUG00000018612	ADRBK1
3		EKS-TAR-00065	ENSTRUG00000018619
4		EKS-TAR-00068	ENSTRUG00000006176	GRK7 (1 of 2)
5		EKS-TAR-00060	ENSTRUG00000005782	GRK4
6		EKS-TAR-00061	ENSTRUG00000001036	GRK6
7		EKS-TAR-00069	ENSTRUG00000000698	GRK7 (2 of 2)
8		EKS-TAR-00064	ENSTRUG00000016449
9		EKS-TAR-00062	ENSTRUG00000003212
10		EKS-TAR-00067	ENSTRUG00000017218	GRK1 (1 of 2)