※ GRK family introduction

    GRK (G protein-coupled receptor (GPCR) kinases), belong to the AGC family, are characterized by its role in relation with GPCR. GPCRs are multi-domain proteins, including an N-termainal unique region, a regulator of G protein signaling (RGS) homology domain (RH) and a kinase catalytic domain. The C-terminal domain is involved in their membrane targeting. GRK isoforms have been shown to target to specialized membrane compartments in specific cell types, which is suggested to have relation with their specific function. GRK is directly activated by docking with active GPCRs and GRK can phosphorylate the Serine/Threonine residue on active GPCR and regulation de downstream signaling. Besides GPCR, GRK can also mediate the phosphorylation of non-GPCR receptors including LRP6, PDGFRb, DREAM, NFkB1 and Nedd4, and involved in specific cellular processes or cell signaling cascade (1).

Reference
1. Gurevich, E.V., Tesmer, J.J., Mushegian, A. and Gurevich, V.V. (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther, 133, 40-69. PMID: 21903131

  Reviewed (0)  or Unreviewed (9) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00064	ENSTNIG00000012051	GRK4
2		EKS-TEN-00067	ENSTNIG00000013888	GRK1 (2 of 2)
3		EKS-TEN-00065	ENSTNIG00000013583	ADRBK2
4		EKS-TEN-00069	ENSTNIG00000013589
5		EKS-TEN-00066	ENSTNIG00000009451	GRK1 (1 of 2)
6		EKS-TEN-00072	ENSTNIG00000019847	GRK7 (1 of 2)
7		EKS-TEN-00068	ENSTNIG00000011762
8		EKS-TEN-00071	ENSTNIG00000007842	GRK7 (2 of 2); GSTENG00014998001
9		EKS-TEN-00070	ENSTNIG00000007615	GRK6