※ MAST family introduction

    MASTs (Microtubule-associated Serine/Threonine-protein kinases) belong to AGC family. The MAST kinases are characterized by the presence of a Serine/Threonine kinase domain, a second 3' MAST domain and PDZ domain. The PDZ domain has been reported to mediate interaction with others proteins and help MAST facilitate functionally important phosphorylation. The N-terminal kinase catalytic domain is relatively conserved in MAST family, with a high degree identity (>60%). MAST family is expressed in multiple tissues. In nervous system, MAST may act as a key role through localization within the DAPC/UAPC, which is found within region of the neuromuscular junction (NMJ) and central synapses (1). Recently gene rearrangements involving MAST and Notch have been reported. Overexpression of MAST1 or MAST2 gene fusions plays an important effect on proliferative (2).

Reference
1. Garland, P., Quraishe, S., French, P. and O'Connor, V. (2008) Expression of the MAST family of serine/threonine kinases. Brain Res, 1195, 12-19. PMID: 18206861
2. Robinson, D.R., Kalyana-Sundaram, S., Wu, Y.M., Shankar, S., Cao, X., Ateeq, B., Asangani, I.A., Iyer, M., Maher, C.A., Grasso, C.S. et al. (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med, 17, 1646-1651 PMID: 22101766

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRR-01571	Bra022251	Bra022251
2		EKS-BRR-01572	Bra018730	Bra018730
3		EKS-BRR-01574	Bra021278	Bra021278
4		EKS-BRR-01573	Bra014141	Bra014141
5		EKS-BRR-01576	Bra014042	Bra014042
6		EKS-BRR-01575	Bra010074	Bra010074