※ MAST family introduction

    MASTs (Microtubule-associated Serine/Threonine-protein kinases) belong to AGC family. The MAST kinases are characterized by the presence of a Serine/Threonine kinase domain, a second 3' MAST domain and PDZ domain. The PDZ domain has been reported to mediate interaction with others proteins and help MAST facilitate functionally important phosphorylation. The N-terminal kinase catalytic domain is relatively conserved in MAST family, with a high degree identity (>60%). MAST family is expressed in multiple tissues. In nervous system, MAST may act as a key role through localization within the DAPC/UAPC, which is found within region of the neuromuscular junction (NMJ) and central synapses (1). Recently gene rearrangements involving MAST and Notch have been reported. Overexpression of MAST1 or MAST2 gene fusions plays an important effect on proliferative (2).

Reference
1. Garland, P., Quraishe, S., French, P. and O'Connor, V. (2008) Expression of the MAST family of serine/threonine kinases. Brain Res, 1195, 12-19. PMID: 18206861
2. Robinson, D.R., Kalyana-Sundaram, S., Wu, Y.M., Shankar, S., Cao, X., Ateeq, B., Asangani, I.A., Iyer, M., Maher, C.A., Grasso, C.S. et al. (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med, 17, 1646-1651 PMID: 22101766

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORN-00259	ENSONIG00000011071	MAST4
2		EKS-ORN-00262	ENSONIG00000008189	MAST1 (1 of 2)
3		EKS-ORN-00258	ENSONIG00000007847	MAST2
4		EKS-ORN-00263	ENSONIG00000010481	MAST3 (2 of 2)
5		EKS-ORN-00260	ENSONIG00000018034	MAST1 (2 of 2)
6		EKS-ORN-00264	ENSONIG00000006385	MASTL
7		EKS-ORN-00261	ENSONIG00000012633	MAST3 (1 of 2)