※ MAST family introduction

    MASTs (Microtubule-associated Serine/Threonine-protein kinases) belong to AGC family. The MAST kinases are characterized by the presence of a Serine/Threonine kinase domain, a second 3' MAST domain and PDZ domain. The PDZ domain has been reported to mediate interaction with others proteins and help MAST facilitate functionally important phosphorylation. The N-terminal kinase catalytic domain is relatively conserved in MAST family, with a high degree identity (>60%). MAST family is expressed in multiple tissues. In nervous system, MAST may act as a key role through localization within the DAPC/UAPC, which is found within region of the neuromuscular junction (NMJ) and central synapses (1). Recently gene rearrangements involving MAST and Notch have been reported. Overexpression of MAST1 or MAST2 gene fusions plays an important effect on proliferative (2).

Reference
1. Garland, P., Quraishe, S., French, P. and O'Connor, V. (2008) Expression of the MAST family of serine/threonine kinases. Brain Res, 1195, 12-19. PMID: 18206861
2. Robinson, D.R., Kalyana-Sundaram, S., Wu, Y.M., Shankar, S., Cao, X., Ateeq, B., Asangani, I.A., Iyer, M., Maher, C.A., Grasso, C.S. et al. (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med, 17, 1646-1651 PMID: 22101766

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-XIM-00256	ENSXMAG00000011272	MAST3 (2 of 2)
2		EKS-XIM-00254	ENSXMAG00000006471	MAST3 (1 of 2)
3		EKS-XIM-00255	ENSXMAG00000006970
4		EKS-XIM-00257	ENSXMAG00000008347	MASTL
5		EKS-XIM-00252	ENSXMAG00000005398	MAST2
6		EKS-XIM-00253	ENSXMAG00000009142