※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belong to AGC family. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consist of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contain two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP, PKA obtain its catalytic activity only after binds to the two binding sites on regulatory subunits. PKA involve in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates, including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

  Reviewed (0)  or Unreviewed (5) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PHP-00685	PP1S88_186V6
2		EKS-PHP-00684	PP1S81_123V6	A9SIB5_PHYPA; PHYPADRAFT_185240
3		EKS-PHP-00681	PP1S59_88V6
4		EKS-PHP-00683	PP1S36_201V6
5		EKS-PHP-00682	PP1S69_82V6	A9SDZ8_PHYPA; PHYPADRAFT_128348