※ PKA family introduction

    PKA (cAMP-dependent protein kinase) belong to AGC family. PKA is characterized by its role as important downstream effecter of second messenger cAMP. PKA consist of multiple forms of regulatory and catalytic subunits and PKA holoenzyme contain two regulatory subunits and two catalytic subunits, which determines the biochemical and functional features. PKA keeps catalytically inactive under low levels of cAMP, PKA obtain its catalytic activity only after binds to the two binding sites on regulatory subunits. PKA involve in a varieties of cellular processes through phosphorylation of different nuclear and cytoplasmic substrates, including metabolism, differentiation, synaptic transmission, ion channel activity, growth and development (1).

Reference
1. Feliciello, A., Gottesman, M.E. and Avvedimento, E.V. (2005) cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal, 17, 279-287. PMID: 15567059

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-00943	SELMODRAFT_124622	SELMODRAFT_124622
2		EKS-SEM-00944	SELMODRAFT_99275	SELMODRAFT_99275
3		EKS-SEM-00946	SELMODRAFT_440463	SELMODRAFT_440463
4		EKS-SEM-00941	SELMODRAFT_137987	SELMODRAFT_137987
5		EKS-SEM-00945	SELMODRAFT_443005	SELMODRAFT_443005
6		EKS-SEM-00942	SELMODRAFT_110120	SELMODRAFT_110120