※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays a important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylate Ser5 in CTD domain of RNA polymerase II and play a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also act as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-LOA-00064	ENSLAFG00000023374	CTDSP1
2		EPS-LOA-00067	ENSLAFG00000011908	UBLCP1
3		EPS-LOA-00063	ENSLAFG00000006997	CTDSPL
4		EPS-LOA-00068	ENSLAFG00000018621	CTDP1
5		EPS-LOA-00061	ENSLAFG00000009263	CTDSPL2
6		EPS-LOA-00062	ENSLAFG00000000746	CTDNEP1
7		EPS-LOA-00066	ENSLAFG00000023081	TIMM50
8		EPS-LOA-00065	ENSLAFG00000010800	CTDSP2