※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays a important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylate Ser5 in CTD domain of RNA polymerase II and play a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also act as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-PEM-00050	ENSPMAG00000003994	TIMM50
2		EPS-PEM-00046	ENSPMAG00000000998	CTDSPL2 (2 of 3)
3		EPS-PEM-00047	ENSPMAG00000009544	CTDSPL
4		EPS-PEM-00051	ENSPMAG00000008480	CTDSPL2 (3 of 3)
5		EPS-PEM-00052	ENSPMAG00000005431	CTDP1
6		EPS-PEM-00045	ENSPMAG00000009781	CTDSPL2 (1 of 3)
7		EPS-PEM-00053	ENSPMAG00000008382	CTDNEP1
8		EPS-PEM-00049	ENSPMAG00000005326	CTDSP1
9		EPS-PEM-00048	ENSPMAG00000003567	CTDSP2