※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays a important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylate Ser5 in CTD domain of RNA polymerase II and play a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also act as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SEM-00200	SELMODRAFT_405568	SELMODRAFT_405568
2		EPS-SEM-00213	SELMODRAFT_421682	SELMODRAFT_421682
3		EPS-SEM-00207	SELMODRAFT_111225	SELMODRAFT_111225
4		EPS-SEM-00210	SELMODRAFT_111624	SELMODRAFT_111624
5		EPS-SEM-00181	SELMODRAFT_58587	SELMODRAFT_58587
6		EPS-SEM-00204	SELMODRAFT_424076	SELMODRAFT_424076
7		EPS-SEM-00153	SELMODRAFT_133639	SELMODRAFT_133639
8		EPS-SEM-00145	SELMODRAFT_424005	SELMODRAFT_424005
9		EPS-SEM-00203	SELMODRAFT_424001	SELMODRAFT_424001
10		EPS-SEM-00147	SELMODRAFT_123069	SELMODRAFT_123069
11		EPS-SEM-00212	SELMODRAFT_406696	SELMODRAFT_406696
12		EPS-SEM-00214	SELMODRAFT_406688	SELMODRAFT_406688
13		EPS-SEM-00162	SELMODRAFT_131171	SELMODRAFT_131171
14		EPS-SEM-00215	SELMODRAFT_443858	SELMODRAFT_443858
15		EPS-SEM-00217	SELMODRAFT_441087	SELMODRAFT_441087
16		EPS-SEM-00164	SELMODRAFT_87588	SELMODRAFT_87588
17		EPS-SEM-00138	SELMODRAFT_129286	SELMODRAFT_129286
18		EPS-SEM-00206	SELMODRAFT_36536	SELMODRAFT_36536
19		EPS-SEM-00177	SELMODRAFT_427569	SELMODRAFT_427569
20		EPS-SEM-00159	SELMODRAFT_137174	SELMODRAFT_137174
21		EPS-SEM-00191	SELMODRAFT_424529	SELMODRAFT_424529
22		EPS-SEM-00179	SELMODRAFT_408265	SELMODRAFT_408265
23		EPS-SEM-00144	SELMODRAFT_123223	SELMODRAFT_123223
24		EPS-SEM-00202	SELMODRAFT_126324	SELMODRAFT_126324
25		EPS-SEM-00208	SELMODRAFT_439199	SELMODRAFT_439199
26		EPS-SEM-00175	SELMODRAFT_129025	SELMODRAFT_129025
27		EPS-SEM-00198	SELMODRAFT_417095	SELMODRAFT_417095
28		EPS-SEM-00142	SELMODRAFT_121282	SELMODRAFT_121282
29		EPS-SEM-00192	SELMODRAFT_411029	SELMODRAFT_411029
30		EPS-SEM-00163	SELMODRAFT_135380	SELMODRAFT_135380
31		EPS-SEM-00193	SELMODRAFT_418187	SELMODRAFT_418187
32		EPS-SEM-00146	SELMODRAFT_48489	SELMODRAFT_48489
33		EPS-SEM-00209	SELMODRAFT_431873	SELMODRAFT_431873
34		EPS-SEM-00190	SELMODRAFT_411169	SELMODRAFT_411169
35		EPS-SEM-00182	SELMODRAFT_411177	SELMODRAFT_411177
36		EPS-SEM-00195	SELMODRAFT_7432	SELMODRAFT_7432
37		EPS-SEM-00201	SELMODRAFT_426476	SELMODRAFT_426476
38		EPS-SEM-00176	SELMODRAFT_131706	SELMODRAFT_131706; SELMODRAFT_131706, SELMODRAFT_131775
39		EPS-SEM-00160	SELMODRAFT_103542	SELMODRAFT_103542
40		EPS-SEM-00167	SELMODRAFT_4536	SELMODRAFT_4536
41		EPS-SEM-00143	SELMODRAFT_121036	SELMODRAFT_121036; SELMODRAFT_121036, SELMODRAFT_121271
42		EPS-SEM-00183	SELMODRAFT_418345	SELMODRAFT_418345
43		EPS-SEM-00189	SELMODRAFT_418336	SELMODRAFT_418336
44		EPS-SEM-00196	SELMODRAFT_418315	SELMODRAFT_418315
45		EPS-SEM-00137	SELMODRAFT_126751	SELMODRAFT_126751, SELMODRAFT_131611; SELMODRAFT_126751
46		EPS-SEM-00185	SELMODRAFT_415773	SELMODRAFT_415773
47		EPS-SEM-00205	SELMODRAFT_425135	SELMODRAFT_425135
48		EPS-SEM-00171	SELMODRAFT_108059	SELMODRAFT_108059
49		EPS-SEM-00149	SELMODRAFT_121192	SELMODRAFT_121192
50		EPS-SEM-00173	SELMODRAFT_85337	SELMODRAFT_85337
51		EPS-SEM-00158	SELMODRAFT_5836	SELMODRAFT_5836
52		EPS-SEM-00141	SELMODRAFT_5868	SELMODRAFT_5868
53		EPS-SEM-00184	SELMODRAFT_5876	SELMODRAFT_5876; SELMODRAFT_5876, SELMODRAFT_5881
54		EPS-SEM-00157	SELMODRAFT_5873	SELMODRAFT_5873
55		EPS-SEM-00186	SELMODRAFT_442163	SELMODRAFT_442163
56		EPS-SEM-00148	SELMODRAFT_121210	SELMODRAFT_121210
57		EPS-SEM-00199	SELMODRAFT_440109	SELMODRAFT_440109
58		EPS-SEM-00188	SELMODRAFT_23521	SELMODRAFT_23521; SELMODRAFT_23521, SELMODRAFT_23523
59		EPS-SEM-00174	SELMODRAFT_415093	SELMODRAFT_415093
60		EPS-SEM-00172	SELMODRAFT_415083	SELMODRAFT_415083
61		EPS-SEM-00194	SELMODRAFT_167775	SELMODRAFT_167775
62		EPS-SEM-00165	SELMODRAFT_75138	SELMODRAFT_75138
63		EPS-SEM-00187	SELMODRAFT_405868	SELMODRAFT_405868
64		EPS-SEM-00168	SELMODRAFT_137927	SELMODRAFT_137927
65		EPS-SEM-00140	SELMODRAFT_131302	SELMODRAFT_131302
66		EPS-SEM-00166	SELMODRAFT_124475	SELMODRAFT_124475; SELMODRAFT_124475, SELMODRAFT_132250
67		EPS-SEM-00170	SELMODRAFT_137904	SELMODRAFT_137904
68		EPS-SEM-00197	SELMODRAFT_79490	SELMODRAFT_79490; SELMODRAFT_174307, SELMODRAFT_79490
69		EPS-SEM-00150	SELMODRAFT_122967	SELMODRAFT_122967
70		EPS-SEM-00139	SELMODRAFT_77112	SELMODRAFT_77112
71		EPS-SEM-00152	SELMODRAFT_423987	SELMODRAFT_423987
72		EPS-SEM-00178	SELMODRAFT_402603	SELMODRAFT_402603
73		EPS-SEM-00156	SELMODRAFT_5512	SELMODRAFT_5512
74		EPS-SEM-00136	SELMODRAFT_125729	SELMODRAFT_125729
75		EPS-SEM-00154	SELMODRAFT_5501	SELMODRAFT_5501
76		EPS-SEM-00155	SELMODRAFT_5502	SELMODRAFT_5502
77		EPS-SEM-00211	SELMODRAFT_417101	SELMODRAFT_417101
78		EPS-SEM-00180	SELMODRAFT_5484	SELMODRAFT_5484
79		EPS-SEM-00151	SELMODRAFT_418692	SELMODRAFT_418692
80		EPS-SEM-00216	SELMODRAFT_32861	SELMODRAFT_32861
81		EPS-SEM-00161	SELMODRAFT_5469	SELMODRAFT_5469
82		EPS-SEM-00169	SELMODRAFT_4374	SELMODRAFT_4374