※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays a important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylate Ser5 in CTD domain of RNA polymerase II and play a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also act as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SEI-00122	Si001967m.g	Si001967m.g
2		EPS-SEI-00120	Si022349m.g	Si022349m.g
3		EPS-SEI-00117	Si010082m.g	Si010082m.g
4		EPS-SEI-00132	Si000422m.g	Si000422m.g
5		EPS-SEI-00129	Si030027m.g	Si030027m.g
6		EPS-SEI-00127	Si002037m.g	Si002037m.g
7		EPS-SEI-00133	Si009341m.g	Si009341m.g
8		EPS-SEI-00131	Si034650m.g	Si034650m.g
9		EPS-SEI-00123	Si002329m.g	Si002329m.g
10		EPS-SEI-00126	Si019418m.g	Si019418m.g
11		EPS-SEI-00125	Si021686m.g	Si021686m.g
12		EPS-SEI-00119	Si001474m.g	Si001474m.g
13		EPS-SEI-00130	Si019173m.g	Si019173m.g
14		EPS-SEI-00118	Si001362m.g	Si001362m.g
15		EPS-SEI-00124	Si022326m.g	Si022326m.g
16		EPS-SEI-00121	Si022793m.g	Si022793m.g
17		EPS-SEI-00128	Si025879m.g	Si025879m.g