※ FCP family introduction

    FCP/SCP phosphatase belongs to a family of phosphatase which uses an Asp nucleophile for catalysis. FCP/SCP is characterized by its phosphatase activity towards the CTD of the largest subunit of RNA polymerase II (1). At least seven members have been identified in human genome and FCP/SCP phosphatases share a conserved catalytic signature, which is known as DXDXT/V (2). Family member FCP1 is conserved among all eukaryotes and plays a important role in cell survival in budding and fission yeasts. SCP1 preferentially dephosphorylate Ser5 in CTD domain of RNA polymerase II and play a role in the regulation of gene expression by controlling the transition from initiation/capping to processive transcript elongation (3). In addition, SCP1 also act as a key regulator that functions in silencing neuronal gene expression (4).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Moorhead, G.B., Trinkle-Mulcahy, L. and Ulke-Lemee, A. (2007) Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol, 8, 234-244. PMID: 17318227
3. Yeo, M., Lin, P.S., Dahmus, M.E. and Gill, G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem, 278, 26078-26085. PMID: 12721286
4. Yeo, M., Lee, S.K., Lee, B., Ruiz, E.C., Pfaff, S.L. and Gill, G.N. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science, 307, 596-600. PMID: 15681389

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SOL-00137	Solyc01g103850.2	Solyc01g103850.2
2		EPS-SOL-00139	Solyc07g005460.2	Solyc07g005460.2
3		EPS-SOL-00131	Solyc04g045630.2	Solyc04g045630.2
4		EPS-SOL-00142	Solyc02g065790.2	Solyc02g065790.2
5		EPS-SOL-00132	Solyc02g071250.2	Solyc02g071250.2
6		EPS-SOL-00144	Solyc12g063050.1	cen12_5; CEN12_5
7		EPS-SOL-00146	Solyc07g065400.2	Solyc07g065400.2
8		EPS-SOL-00133	Solyc02g071930.1	Solyc02g071930.1
9		EPS-SOL-00141	Solyc09g008950.1	Solyc09g008950.1
10		EPS-SOL-00143	Solyc06g069450.2	Solyc06g069450.2
11		EPS-SOL-00147	Solyc09g014440.2	Solyc09g014440.2
12		EPS-SOL-00135	Solyc06g051520.2	Solyc06g051520.2
13		EPS-SOL-00140	Solyc09g008960.1	Solyc09g008960.1
14		EPS-SOL-00136	Solyc10g006020.2	Solyc10g006020.2
15		EPS-SOL-00145	Solyc03g114990.2	Solyc03g114990.2
16		EPS-SOL-00134	Solyc05g052580.2	Solyc05g052580.2
17		EPS-SOL-00138	Solyc07g005450.2	Solyc07g005450.2