Anolis carolinensis      Atypical      ABC1

※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusEKPD IDGene IDGene Name
1
EKS-ANC-00125
ENSACAG00000006522
ADCK3
2
EKS-ANC-00127
ENSACAG00000009746
ADCK5
3
EKS-ANC-00128
ENSACAG00000011163
ADCK2
4
EKS-ANC-00124
ENSACAG00000017313
ADCK1
5
EKS-ANC-00126
ENSACAG00000013436
ADCK4