Bos taurus      Atypical      ABC1

※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (1 or Unreviewed (4

No.StatusEKPD IDGene IDGene Name
1
EKS-BOT-00135
ENSBTAG00000011064
ADCK5
2
EKS-BOT-00136
ENSBTAG00000020484
ADCK2
3
EKS-BOT-00133
ENSBTAG00000021880
CABC1; ADCK3
4
EKS-BOT-00134
ENSBTAG00000019462
ADCK4
5
EKS-BOT-00132
ENSBTAG00000012106
BT.63691; ADCK1