Latimeria chalumnae      Atypical      ABC1

※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusEKPD IDGene IDGene Name
1
EKS-LAC-00140
ENSLACG00000018738
ADCK4
2
EKS-LAC-00142
ENSLACG00000018084
3
EKS-LAC-00143
ENSLACG00000010013
ADCK2
4
EKS-LAC-00144
ENSLACG00000003697
ADCK5
5
EKS-LAC-00139
ENSLACG00000007098
ADCK3
6
EKS-LAC-00141
ENSLACG00000011987
ADCK1