Oreochromis niloticus      Atypical      ABC1

※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusEKPD IDGene IDGene Name
1
EKS-ORN-00164
ENSONIG00000008815
ADCK2
2
EKS-ORN-00159
ENSONIG00000011041
ADCK1
3
EKS-ORN-00163
ENSONIG00000007683
ADCK5
4
EKS-ORN-00162
ENSONIG00000000575
ADCK3 (2 of 2); ADCK3 (1 of 2)
5
EKS-ORN-00160
ENSONIG00000016647
ADCK4
6
EKS-ORN-00161
ENSONIG00000000696
ADCK3 (2 of 2); ADCK3 (1 of 2)