Oryzias latipes      Atypical      ABC1

※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusEKPD IDGene IDGene Name
1
EKS-ORL-00152
ENSORLG00000017137
ADCK3 (2 of 2); ADCK3 (1 of 2)
2
EKS-ORL-00151
ENSORLG00000013555
ADCK5
3
EKS-ORL-00150
ENSORLG00000008795
ADCK4
4
EKS-ORL-00149
ENSORLG00000010777
ADCK1
5
EKS-ORL-00153
ENSORLG00000019784
ADCK3 (2 of 2); ADCK3 (1 of 2)
6
EKS-ORL-00154
ENSORLG00000002597
ADCK2