※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PAT-00285	ENSPTRG00000021026	ENSG00000119121; TRPM6
2		EKS-PAT-00289	ENSPTRG00000010052	ALPK2; ENSG00000198796
3		EKS-PAT-00288	ENSPTRG00000016375	ALPK1; ENSG00000073331
4		EKS-PAT-00287	ENSPTRG00000007877	ENSG00000103319; EEF2K
5		EKS-PAT-00286	ENSPTRG00000007068	TRPM7; ENSG00000092439
6		EKS-PAT-00290	ENSPTRG00000007406	ALPK3