Anolis carolinensis      Atypical      PDHK

※ PDHK family introduction

    PDHK (Pyruvate Dehydrogenase Kinases) belong to atypical kinase group (1). PDHKs are related to histidine kinases, but the phosphorylation site is serine rather than histidine or aspartate. The structure analysis shows that PDHKs contain an N-terminal BCDHK_Adom3 domain and a C-terminal histidine kinase-like domain. The only substrate of PDHK is the E1 subunits of Pyruvate Dehydrogenase (PDH) and the phosphorylation occurs on three serine residues S230, S293 and S300 in human. PDHK is associated with diseases and can be a target for diabetes therapies (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation: Kinase Family PDHK


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusEKPD IDGene IDGene Name
1
EKS-ANC-00436
ENSACAG00000014020
PDK4
2
EKS-ANC-00437
ENSACAG00000006961
BCKDK
3
EKS-ANC-00434
ENSACAG00000007063
PDK3
4
EKS-ANC-00433
ENSACAG00000015877
PDK1
5
EKS-ANC-00435
ENSACAG00000005384
PDK2