※ PDHK family introduction

    PDHK (Pyruvate Dehydrogenase Kinases) belong to atypical kinase group (1). PDHKs are related to histidine kinases, but the phosphorylation site is serine rather than histidine or aspartate. The structure analysis shows that PDHKs contain an N-terminal BCDHK_Adom3 domain and a C-terminal histidine kinase-like domain. The only substrate of PDHK is the E1 subunits of Pyruvate Dehydrogenase (PDH) and the phosphorylation occurs on three serine residues S230, S293 and S300 in human. PDHK is associated with diseases and can be a target for diabetes therapies (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation: Kinase Family PDHK

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORC-00423	ENSOCUG00000002290	BCKDK
2		EKS-ORC-00419	ENSOCUG00000007418	PDK3
3		EKS-ORC-00424	ENSOCUG00000027656
4		EKS-ORC-00420	ENSOCUG00000017120	PDK4
5		EKS-ORC-00417	ENSOCUG00000000408	PDK1
6		EKS-ORC-00421	ENSOCUG00000022357	PDK2
7		EKS-ORC-00418	ENSOCUG00000025698
8		EKS-ORC-00422	ENSOCUG00000025831