※ PDHK family introduction

    PDHK (Pyruvate Dehydrogenase Kinases) belong to atypical kinase group (1). PDHKs are related to histidine kinases, but the phosphorylation site is serine rather than histidine or aspartate. The structure analysis shows that PDHKs contain an N-terminal BCDHK_Adom3 domain and a C-terminal histidine kinase-like domain. The only substrate of PDHK is the E1 subunits of Pyruvate Dehydrogenase (PDH) and the phosphorylation occurs on three serine residues S230, S293 and S300 in human. PDHK is associated with diseases and can be a target for diabetes therapies (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation: Kinase Family PDHK

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SAH-00413	ENSSHAG00000002941	PDK4
2		EKS-SAH-00412	ENSSHAG00000017496	PDK1
3		EKS-SAH-00415	ENSSHAG00000012889	PDK2
4		EKS-SAH-00416	ENSSHAG00000011710	BCKDK
5		EKS-SAH-00414	ENSSHAG00000015104	PDK3