※ CAMK1 family introduction

    CAMK1 family consists of six family members in human. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Family member CAMK1 is a monomeric 42KD enzyme distributed in most mammalian cell types. CAMK1 contains a protein kinase catalytic domain flanked by an ATP bind lobe and protein substrates bind lobe. CAMK1 keeps an inhibited state normally, with the ATP binding lobe interacting with AID domain. Active CAMK1 prefer the substrate containing a basic residue at the P-3 position and a hydrophobic residue at P-5 (1). CAMK1 act as a key molecule in calcium-triggered CaMKK-CaMK1 signaling cascade, and regulates a variety of cellular processes including transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, neurite outgrowth and also involve in regulation of axonal extension and growth cone motility in hippocampal and cerebellar nerve cells (2).

Reference
1. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376
2. Kamata, A., Sakagami, H., Tokumitsu, H., Owada, Y., Fukunaga, K. and Kondo, H. (2007) Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res, 57, 86-97. PMID: 17056143

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRR-01564	Bra036512	Bra036512
2		EKS-BRR-01565	Bra009765	Bra009765
3		EKS-BRR-01562	Bra022388	Bra022388
4		EKS-BRR-01561	Bra037539	Bra037539
5		EKS-BRR-01563	Bra001734	Bra001734
6		EKS-BRR-01560	Bra026489	Bra026489