※ CAMK2 family introduction

    CAMK2 (Calcium/calmodulin-dependent protein kinase type II) belong to the CAMK family. CAMK2 is a key mediator of Ca2+ signaling. CAMK2 obtain its kinase catalytic activity fowling by binding of Ca2+/Calmodulin on its CAM binding domain. In addition, CAMK2 also undergoes multiple autoregulatory states through phosphorylation of on autoregulatory domain or CAM binding domain. Each phosphorylation state of CAMK2 can regulate related physiological targets (1). Studies show that CAMK2 is involved in sarcoplamic reticulum Ca2+ transport in skeletal muscle and function in dendritic spine and synapse formation and neuronal plasticity (2). CAMK2 also plays an important role in keep de synaptic plasticity which enables LTP and hippocampus-dependent learning (3).

Reference
1. Hudmon, A. and Schulman, H. (2002) Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. Biochem J, 364, 593-611. PMID: 11931644
2. Rose, A.J., Kiens, B. and Richter, E.A. (2006) Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. J Physiol, 574, 889-903 PMID: 16690701
3. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376

  Reviewed (2)  or Unreviewed (2) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BOT-00478	ENSBTAG00000020087	CAMK2A
2		EKS-BOT-00476	ENSBTAG00000014463	CAMK2D
3		EKS-BOT-00479	ENSBTAG00000012667	CAMK2G; BT.103020
4		EKS-BOT-00477	ENSBTAG00000012653	CAMK2B