※ CAMKL family introduction

    CAMKL family consists of several subfamily including SNRK, QIK, BRSK, AMPK, MARK, NuaK, NIM1, HUNK, LKB, PASK, MELK and CHK1. They are classified into CAMKL family for the high similarity kinase catalytic domain.
AMPK subfamily (AMP-activated protein kinase) consists of three subunits, a catalytic subunit (α) and two regulatory subunits (β and γ). Two catalytic subunits have been identified in mammals. Activation of AMPK is involved in two steps; first, AMP binds to γ-subunit, and second the phosphorylation of threonine 172 by LKB1. Activated AMPK target a variety of substrates and participate different cellular processes, including mTORC1 signaling, phosphorylation of p53 or other tumor suppressors (1).
MARK subfamily (microtubule-affinity regulating kinases) consists of four members (MARK1-MARK4) in mammals cells. All isoforms contain a N-terminal header, a catalytic kinase domain, a ubiquitin-associated domain, a spacer domain and a C-terminal KA1 domain. MARKs are discovered for its ability to regulate the stability of microtubules. Studies also show that MARK has some relation with disease, such as Alzheimer's disease (2).
Nuak subfamilies are AMPK related kinases. NuaK1 are stress-activated kinase which is involved in tolerance to glucose starvation. NuaK1 can induce cell-cell detachment by increasing F-actin conversion to G-actin. NuaK1 can protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells (3).

Reference
1. Luo, Z., Zang, M. and Guo, W. (2010) AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol, 6, 457-470. PMID: 20222801
2. Matenia, D. and Mandelkow, E.M. (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci, 34, 332-342. PMID: 19559622
3. Suzuki, A., Kusakai, G., Kishimoto, A., Minegichi, Y., Ogura, T. and Esumi, H. (2003) Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun, 311, 156-161. PMID: 14575707

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GLM-00063	GLYMA19G05410
2		EKS-GLM-00076	GLYMA05G31000
3		EKS-GLM-00012	GLYMA05G29140
4		EKS-GLM-00023	GLYMA18G44450
5		EKS-GLM-00049	GLYMA14G04433
6		EKS-GLM-00064	GLYMA05G05540
7		EKS-GLM-00045	GLYMA18G44510
8		EKS-GLM-00015	GLYMA17G07370
9		EKS-GLM-00042	GLYMA02G36410
10		EKS-GLM-00081	GLYMA15G09030
11		EKS-GLM-00025	GLYMA15G09040
12		EKS-GLM-00056	GLYMA14G35380
13		EKS-GLM-00055	GLYMA20G35320
14		EKS-GLM-00068	GLYMA06G16780
15		EKS-GLM-00043	GLYMA11G30040
16		EKS-GLM-00030	GLYMA04G09610
17		EKS-GLM-00005	GLYMA18G49770
18		EKS-GLM-00013	GLYMA07G05700
19		EKS-GLM-00034	GLYMA09G14090
20		EKS-GLM-00024	GLYMA13G23500
21		EKS-GLM-00062	GLYMA08G14210
22		EKS-GLM-00061	GLYMA02G15330
23		EKS-GLM-00047	GLYMA11G30110
24		EKS-GLM-00010	GLYMA17G12250
25		EKS-GLM-00017	GLYMA16G02290
26		EKS-GLM-00031	GLYMA15G00581
27		EKS-GLM-00054	GLYMA02G37090
28		EKS-GLM-00070	GLYMA08G10470
29		EKS-GLM-00073	GLYMA12G07340
30		EKS-GLM-00028	GLYMA06G09700
31		EKS-GLM-00041	GLYMA04G06520
32		EKS-GLM-00008	GLYMA02G44380
33		EKS-GLM-00029	GLYMA02G40110
34		EKS-GLM-00039	GLYMA02G40130
35		EKS-GLM-00058	GLYMA07G33120
36		EKS-GLM-00014	GLYMA13G17990
37		EKS-GLM-00036	GLYMA11G35900
38		EKS-GLM-00003	GLYMA13G05700
39		EKS-GLM-00066	GLYMA01G39020
40		EKS-GLM-00004	GLYMA08G26180
41		EKS-GLM-00006	GLYMA08G26191
42		EKS-GLM-00020	GLYMA15G21340
43		EKS-GLM-00051	GLYMA10G00430
44		EKS-GLM-00059	GLYMA05G33170
45		EKS-GLM-00037	GLYMA18G02500
46		EKS-GLM-00078	GLYMA03G04510
47		EKS-GLM-00032	GLYMA14G38337
48		EKS-GLM-00018	GLYMA02G38180
49		EKS-GLM-00009	GLYMA09G09310
50		EKS-GLM-00007	GLYMA09G11770
51		EKS-GLM-00046	GLYMA09G41300
52		EKS-GLM-00027	GLYMA09G41340
53		EKS-GLM-00011	GLYMA01G32400
54		EKS-GLM-00075	GLYMA14G14100
55		EKS-GLM-00069	GLYMA04G38270	SPK-4
56		EKS-GLM-00026	GLYMA13G30100
57		EKS-GLM-00048	GLYMA13G30110
58		EKS-GLM-00016	GLYMA08G23340
59		EKS-GLM-00080	GLYMA08G27900
60		EKS-GLM-00072	GLYMA04G15066
61		EKS-GLM-00079	GLYMA16G25426
62		EKS-GLM-00022	GLYMA17G04540
63		EKS-GLM-00071	GLYMA11G20690
64		EKS-GLM-00040	GLYMA03G42130
65		EKS-GLM-00053	GLYMA12G29130
66		EKS-GLM-00021	GLYMA08G12290
67		EKS-GLM-00035	GLYMA18G06180
68		EKS-GLM-00050	GLYMA18G06130
69		EKS-GLM-00038	GLYMA15G32800	GMA.16606
70		EKS-GLM-00057	GLYMA10G32280
71		EKS-GLM-00033	GLYMA06G06550
72		EKS-GLM-00019	GLYMA07G02660
73		EKS-GLM-00067	GLYMA11G06250
74		EKS-GLM-00044	GLYMA17G08270
75		EKS-GLM-00077	GLYMA19G28790
76		EKS-GLM-00052	GLYMA08G20090
77		EKS-GLM-00065	GLYMA17G15860
78		EKS-GLM-00074	GLYMA02G35951
79		EKS-GLM-00060	GLYMA08G00770	SPK-3