※ CAMKL family introduction

    CAMKL family consists of several subfamily including SNRK, QIK, BRSK, AMPK, MARK, NuaK, NIM1, HUNK, LKB, PASK, MELK and CHK1. They are classified into CAMKL family for the high similarity kinase catalytic domain.
AMPK subfamily (AMP-activated protein kinase) consists of three subunits, a catalytic subunit (α) and two regulatory subunits (β and γ). Two catalytic subunits have been identified in mammals. Activation of AMPK is involved in two steps; first, AMP binds to γ-subunit, and second the phosphorylation of threonine 172 by LKB1. Activated AMPK target a variety of substrates and participate different cellular processes, including mTORC1 signaling, phosphorylation of p53 or other tumor suppressors (1).
MARK subfamily (microtubule-affinity regulating kinases) consists of four members (MARK1-MARK4) in mammals cells. All isoforms contain a N-terminal header, a catalytic kinase domain, a ubiquitin-associated domain, a spacer domain and a C-terminal KA1 domain. MARKs are discovered for its ability to regulate the stability of microtubules. Studies also show that MARK has some relation with disease, such as Alzheimer's disease (2).
Nuak subfamilies are AMPK related kinases. NuaK1 are stress-activated kinase which is involved in tolerance to glucose starvation. NuaK1 can induce cell-cell detachment by increasing F-actin conversion to G-actin. NuaK1 can protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells (3).

Reference
1. Luo, Z., Zang, M. and Guo, W. (2010) AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol, 6, 457-470. PMID: 20222801
2. Matenia, D. and Mandelkow, E.M. (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci, 34, 332-342. PMID: 19559622
3. Suzuki, A., Kusakai, G., Kishimoto, A., Minegichi, Y., Ogura, T. and Esumi, H. (2003) Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun, 311, 156-161. PMID: 14575707

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-00439	SELMODRAFT_175338	SELMODRAFT_175338
2		EKS-SEM-00432	SELMODRAFT_232364	SELMODRAFT_232364
3		EKS-SEM-00441	SELMODRAFT_162233	SELMODRAFT_162233; OST1-2
4		EKS-SEM-00428	SELMODRAFT_135824	SELMODRAFT_135824; CIPK04
5		EKS-SEM-00440	SELMODRAFT_158991	OST1-1; SELMODRAFT_158991
6		EKS-SEM-00431	SELMODRAFT_90416	SELMODRAFT_90416; CIPK02
7		EKS-SEM-00435	SELMODRAFT_269551	SELMODRAFT_269551
8		EKS-SEM-00429	SELMODRAFT_137499	SELMODRAFT_137499
9		EKS-SEM-00444	SELMODRAFT_35928	SELMODRAFT_35928
10		EKS-SEM-00445	SELMODRAFT_35929	SELMODRAFT_35929
11		EKS-SEM-00427	SELMODRAFT_233667	SELMODRAFT_233667
12		EKS-SEM-00425	SELMODRAFT_450254	SELMODRAFT_450254; SNRK1.2-1
13		EKS-SEM-00424	SELMODRAFT_450118	SnRK1.2-2; SELMODRAFT_450118
14		EKS-SEM-00426	SELMODRAFT_234034	SELMODRAFT_234034
15		EKS-SEM-00430	SELMODRAFT_132147	SELMODRAFT_132147
16		EKS-SEM-00434	SELMODRAFT_234951	CIPK03; SELMODRAFT_234951
17		EKS-SEM-00436	SELMODRAFT_414787	SELMODRAFT_414787
18		EKS-SEM-00443	SELMODRAFT_119400	SELMODRAFT_119400
19		EKS-SEM-00442	SELMODRAFT_164978	SELMODRAFT_164978; OST3-1
20		EKS-SEM-00438	SELMODRAFT_267186	SELMODRAFT_267186; CIPK05
21		EKS-SEM-00446	SELMODRAFT_79809	SELMODRAFT_79809
22		EKS-SEM-00433	SELMODRAFT_79434	SELMODRAFT_79434; CIPK01
23		EKS-SEM-00437	SELMODRAFT_22400	SELMODRAFT_22400