※ CAMKL family introduction

    CAMKL family consists of several subfamily including SNRK, QIK, BRSK, AMPK, MARK, NuaK, NIM1, HUNK, LKB, PASK, MELK and CHK1. They are classified into CAMKL family for the high similarity kinase catalytic domain.
AMPK subfamily (AMP-activated protein kinase) consists of three subunits, a catalytic subunit (α) and two regulatory subunits (β and γ). Two catalytic subunits have been identified in mammals. Activation of AMPK is involved in two steps; first, AMP binds to γ-subunit, and second the phosphorylation of threonine 172 by LKB1. Activated AMPK target a variety of substrates and participate different cellular processes, including mTORC1 signaling, phosphorylation of p53 or other tumor suppressors (1).
MARK subfamily (microtubule-affinity regulating kinases) consists of four members (MARK1-MARK4) in mammals cells. All isoforms contain a N-terminal header, a catalytic kinase domain, a ubiquitin-associated domain, a spacer domain and a C-terminal KA1 domain. MARKs are discovered for its ability to regulate the stability of microtubules. Studies also show that MARK has some relation with disease, such as Alzheimer's disease (2).
Nuak subfamilies are AMPK related kinases. NuaK1 are stress-activated kinase which is involved in tolerance to glucose starvation. NuaK1 can induce cell-cell detachment by increasing F-actin conversion to G-actin. NuaK1 can protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells (3).

Reference
1. Luo, Z., Zang, M. and Guo, W. (2010) AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol, 6, 457-470. PMID: 20222801
2. Matenia, D. and Mandelkow, E.M. (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem Sci, 34, 332-342. PMID: 19559622
3. Suzuki, A., Kusakai, G., Kishimoto, A., Minegichi, Y., Ogura, T. and Esumi, H. (2003) Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun, 311, 156-161. PMID: 14575707

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEI-00541	Si001185m.g	Si001185m.g
2		EKS-SEI-00551	Si036309m.g	Si036309m.g
3		EKS-SEI-00549	Si022448m.g	Si022448m.g
4		EKS-SEI-00553	Si036041m.g	Si036041m.g
5		EKS-SEI-00527	Si006409m.g	Si006409m.g
6		EKS-SEI-00524	Si029827m.g	Si029827m.g
7		EKS-SEI-00536	Si029831m.g	Si029831m.g
8		EKS-SEI-00550	Si030417m.g	Si030417m.g
9		EKS-SEI-00530	Si029821m.g	Si029821m.g
10		EKS-SEI-00521	Si035270m.g	Si035270m.g
11		EKS-SEI-00560	Si026385m.g	Si026385m.g
12		EKS-SEI-00529	Si021946m.g	Si021946m.g
13		EKS-SEI-00543	Si001288m.g	Si001288m.g
14		EKS-SEI-00520	Si000965m.g	Si000965m.g
15		EKS-SEI-00535	Si001423m.g	Si001423m.g
16		EKS-SEI-00565	Si026521m.g	Si026521m.g
17		EKS-SEI-00554	Si010093m.g	Si010093m.g
18		EKS-SEI-00538	Si017133m.g	Si017133m.g
19		EKS-SEI-00547	Si022090m.g	Si022090m.g
20		EKS-SEI-00562	Si010180m.g	Si010180m.g
21		EKS-SEI-00542	Si001041m.g	Si001041m.g
22		EKS-SEI-00556	Si017369m.g	Si017369m.g
23		EKS-SEI-00540	Si001420m.g	Si001420m.g
24		EKS-SEI-00566	Si024166m.g	Si024166m.g
25		EKS-SEI-00525	Si029846m.g	Si029846m.g
26		EKS-SEI-00564	Si022225m.g	Si022225m.g
27		EKS-SEI-00534	Si010116m.g	Si010116m.g
28		EKS-SEI-00519	Si021825m.g	Si021825m.g
29		EKS-SEI-00561	Si022378m.g	Si022378m.g
30		EKS-SEI-00558	Si006337m.g	Si006337m.g
31		EKS-SEI-00557	Si019716m.g	Si019716m.g
32		EKS-SEI-00528	Si001346m.g	Si001346m.g
33		EKS-SEI-00555	Si036283m.g	Si036283m.g
34		EKS-SEI-00563	Si005356m.g	Si005356m.g
35		EKS-SEI-00545	Si040877m.g	Si040877m.g
36		EKS-SEI-00537	Si021995m.g	Si021995m.g
37		EKS-SEI-00533	Si035646m.g	Si035646m.g
38		EKS-SEI-00532	Si026369m.g	Si026369m.g
39		EKS-SEI-00531	Si035675m.g	Si035675m.g
40		EKS-SEI-00544	Si029714m.g	Si029714m.g
41		EKS-SEI-00548	Si029903m.g	Si029903m.g
42		EKS-SEI-00559	Si035799m.g	Si035799m.g
43		EKS-SEI-00522	Si010128m.g	Si010128m.g
44		EKS-SEI-00526	Si040049m.g	Si040049m.g
45		EKS-SEI-00539	Si013722m.g	Si013722m.g
46		EKS-SEI-00523	Si026322m.g	Si026322m.g
47		EKS-SEI-00546	Si036531m.g	Si036531m.g
48		EKS-SEI-00552	Si022358m.g	Si022358m.g