※ DAPK family introduction

    DAPK (Death-associated protein kinase) belong to the CAMK family. DAPK contains DAPK1, DAPK, Zipper interacting kinase (ZIPK, also named DAPK-3), DAP kinase related apoptosis inducing protein kinase DRAK1 and DRAK2. They share a highly conserved catalytic domain and diverse extracatalytic domainsm which associated with different functions. DAPK proteins are activated downstream of a variety of cell signaling pathway. And then induce cell death via p53 or p53-independent induced apoptosis, and also via autophagy and membrane blebbing induced cell death. In addition, death signal can also stimuli the DAPK cascade signaling pathway and finally induce cell death (1).

Reference
1. Lin, Y., Hupp, T.R. and Stevens, C. (2010) Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. FEBS J, 277, 48-57. PMID: 19878313

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PES-00368	ENSPSIG00000010970	DAPK3
2		EKS-PES-00370	ENSPSIG00000015800	DAPK2
3		EKS-PES-00371	ENSPSIG00000018051	STK17A
4		EKS-PES-00373	ENSPSIG00000017786
5		EKS-PES-00372	ENSPSIG00000013683	STK17B
6		EKS-PES-00369	ENSPSIG00000003652	DAPK1