※ PIM family introduction

    PIM consists of three members, PIM-1, PIM-2 and PIM-3. Sequence analysis show that PIM-1 and PIM-2 share a sequence identical of 61%, PIM-1 and PIM-3 are 77% identical. PIM kinases play an important role in cancer. PIM-1 and PIM-2 transgenic mice overexpression these genes have been observed to develop lymphomas. In addition, PIM-1 is over expressed in c-myc transgene driven prostate tumors in mice. In human, PIM-1 and PIM-2 are involved in prostate cancer development. Studies show that PIM-3 is over expressed in colorectal, pancreatic and hepatocellular carcinoma. The mechanisms that PIMs implicated in cancer have been reported that PIMs act as key regulator in several major proliferative and survival signaling pathways or influence the activity of specific cell cycle molecules and changes in gene expression (1).

Reference
1. Isaac, M., Siu, A. and Jongstra, J. (2011) The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms. Drug Resist Updat, 14, 203-211. PMID: 21601509

  Reviewed (1)  or Unreviewed (236) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-DAR-00157	ENSDARG00000093132	CR450827.3
2		EKS-DAR-00174	ENSDARG00000006109	si:dkeyp-104h9.7
3		EKS-DAR-00184	ENSDARG00000093154	si:dkey-179a6.1; DKEY-179A6.1-001
4		EKS-DAR-00159	ENSDARG00000093155	BX914219.2; LOC100538327
5		EKS-DAR-00235	ENSDARG00000093178	si:dkey-84o3.12
6		EKS-DAR-00095	ENSDARG00000093226	BX927341.3; LOC100537248
7		EKS-DAR-00100	ENSDARG00000089084	CU137681.6
8		EKS-DAR-00277	ENSDARG00000051894	si:ch211-255l14.3
9		EKS-DAR-00231	ENSDARG00000093032	si:dkey-84o3.11
10		EKS-DAR-00218	ENSDARG00000093004	LOC562179; BX548044.8
11		EKS-DAR-00182	ENSDARG00000077035	CU467982.1
12		EKS-DAR-00154	ENSDARG00000077000	CR450827.1
13		EKS-DAR-00234	ENSDARG00000069901	LOC798984; BX901922.2
14		EKS-DAR-00209	ENSDARG00000069851	DKEY-19P15.5-001; si:dkey-19p15.5
15		EKS-DAR-00224	ENSDARG00000069884	si:dkey-112g5.7
16		EKS-DAR-00237	ENSDARG00000069887	DKEY-33C12.7-001; si:dkey-33c12.7
17		EKS-DAR-00219	ENSDARG00000069863	DKEY-265C15.7-001; si:dkey-265c15.7
18		EKS-DAR-00265	ENSDARG00000077277	LOC797842; CR450805.1
19		EKS-DAR-00194	ENSDARG00000006925	si:dkey-58b18.3
20		EKS-DAR-00141	ENSDARG00000089975	CABZ01086639.3
21		EKS-DAR-00112	ENSDARG00000089956	CABZ01019032.3
22		EKS-DAR-00257	ENSDARG00000037246	si:dkeyp-110e4.3
23		EKS-DAR-00179	ENSDARG00000077621	BX649415.2; si:dkey-40j3.1
24		EKS-DAR-00295	ENSDARG00000089747	FP565451.1
25		EKS-DAR-00125	ENSDARG00000089731	BX511311.7
26		EKS-DAR-00299	ENSDARG00000077665	DKEY-236A14.6-002; si:dkey-236a14.6
27		EKS-DAR-00211	ENSDARG00000089682	BX323556.1
28		EKS-DAR-00106	ENSDARG00000089540	BX511311.6
29		EKS-DAR-00256	ENSDARG00000077814	BX296549.1
30		EKS-DAR-00096	ENSDARG00000089502	CU137681.7; LOC100330398
31		EKS-DAR-00190	ENSDARG00000089294	si:rp71-1l17.1
32		EKS-DAR-00176	ENSDARG00000096374	si:dkey-45d16.8
33		EKS-DAR-00163	ENSDARG00000003209	si:ch73-129a22.11
34		EKS-DAR-00317	ENSDARG00000045282	BX322605.1
35		EKS-DAR-00307	ENSDARG00000069276	si:dkey-197d18.2
36		EKS-DAR-00252	ENSDARG00000069281	si:dkey-14a7.4
37		EKS-DAR-00290	ENSDARG00000052021	CU062431.1
38		EKS-DAR-00201	ENSDARG00000093913	LOC793429; BX548044.10
39		EKS-DAR-00142	ENSDARG00000069470	CR790388.1
40		EKS-DAR-00243	ENSDARG00000052319	CR759882.1
41		EKS-DAR-00121	ENSDARG00000056598	DKEY-45J10.1-001; si:dkey-45j10.1
42		EKS-DAR-00297	ENSDARG00000069445	si:ch211-10j20.2
43		EKS-DAR-00249	ENSDARG00000093878	si:dkey-44g23.9; DKEY-44G23.9-001
44		EKS-DAR-00128	ENSDARG00000056616	si:ch211-194c3.4; CH211-194C3.4-001
45		EKS-DAR-00246	ENSDARG00000052296	si:dkey-183g16.1
46		EKS-DAR-00166	ENSDARG00000093790	si:dkey-205o12.1
47		EKS-DAR-00169	ENSDARG00000056748	CU856174.1; LOC100536890
48		EKS-DAR-00215	ENSDARG00000093700	LOC100333446; BX510654.2
49		EKS-DAR-00261	ENSDARG00000093733	CR450805.2
50		EKS-DAR-00105	ENSDARG00000093631	BX470083.8
51		EKS-DAR-00310	ENSDARG00000093630	si:ch211-249h16.8
52		EKS-DAR-00202	ENSDARG00000093634	si:dkey-112g5.2
53		EKS-DAR-00158	ENSDARG00000056838	LOC100536299; CR848705.1
54		EKS-DAR-00293	ENSDARG00000093653	si:dkey-58b18.6
55		EKS-DAR-00195	ENSDARG00000056876	si:dkey-43b14.9
56		EKS-DAR-00272	ENSDARG00000093534	DKEY-258F14.4-001; si:dkey-258f14.4
57		EKS-DAR-00232	ENSDARG00000093551	BX901922.3
58		EKS-DAR-00305	ENSDARG00000052758	AL845306.1
59		EKS-DAR-00303	ENSDARG00000052733	BX322605.2
60		EKS-DAR-00133	ENSDARG00000093408	si:dkey-1p9.3; DKEY-1P9.3-001, DKEY-236A14.10-001; si:dkey-236a14.10
61		EKS-DAR-00230	ENSDARG00000093451	si:dkey-33c12.6
62		EKS-DAR-00102	ENSDARG00000093388	CR381537.2
63		EKS-DAR-00276	ENSDARG00000033462	BX571981.1; LOC799234
64		EKS-DAR-00291	ENSDARG00000052677	si:ch211-138g9.2
65		EKS-DAR-00111	ENSDARG00000093301	BX927341.4
66		EKS-DAR-00233	ENSDARG00000093310	si:dkey-112g5.6
67		EKS-DAR-00207	ENSDARG00000093314	si:dkey-84o3.10
68		EKS-DAR-00262	ENSDARG00000093330	BX296549.4
69		EKS-DAR-00114	ENSDARG00000093328	BX537296.4
70		EKS-DAR-00286	ENSDARG00000073809	CR936484.2
71		EKS-DAR-00108	ENSDARG00000086018	LOC100536531; BX511311.2
72		EKS-DAR-00280	ENSDARG00000073947	si:dkeyp-67e1.6
73		EKS-DAR-00294	ENSDARG00000073913	si:ch211-215m21.13
74		EKS-DAR-00145	ENSDARG00000086043	si:ch211-155d24.5
75		EKS-DAR-00285	ENSDARG00000030634	si:dkeyp-100a1.5; DKEYP-100A1.5-001
76		EKS-DAR-00120	ENSDARG00000078312	CU137681.1
77		EKS-DAR-00325	ENSDARG00000078162	si:dkey-11f7.5
78		EKS-DAR-00259	ENSDARG00000007864	CR774199.1
79		EKS-DAR-00309	ENSDARG00000078271	si:ch211-57m13.8
80		EKS-DAR-00322	ENSDARG00000078816	si:ch211-215m21.11
81		EKS-DAR-00292	ENSDARG00000030025	AL928870.1
82		EKS-DAR-00283	ENSDARG00000078558	si:dkey-22i16.10
83		EKS-DAR-00225	ENSDARG00000038955	si:dkey-208k22.2
84		EKS-DAR-00240	ENSDARG00000038987	OTTDARG00000024936; si:dkey-31m5.5
85		EKS-DAR-00152	ENSDARG00000038988	FP016152.1
86		EKS-DAR-00092	ENSDARG00000059120	pim1
87		EKS-DAR-00094	ENSDARG00000059001	pim2; pim1; si:dkey-83k24.1
88		EKS-DAR-00248	ENSDARG00000039143	CABZ01059923.1
89		EKS-DAR-00245	ENSDARG00000026569	si:dkey-183g16.2
90		EKS-DAR-00107	ENSDARG00000092897	AL953848.2
91		EKS-DAR-00123	ENSDARG00000092911	CR762392.2
92		EKS-DAR-00213	ENSDARG00000092514	LOC100333507; BX510654.1
93		EKS-DAR-00320	ENSDARG00000092512	si:dkey-93l1.6
94		EKS-DAR-00208	ENSDARG00000092516	BX469935.3; LOC799072
95		EKS-DAR-00301	ENSDARG00000092501	si:dkey-80c24.5; DKEY-80C24.5-001
96		EKS-DAR-00210	ENSDARG00000092544	si:dkey-112g5.3
97		EKS-DAR-00220	ENSDARG00000092589	LOC793868; BX548044.5
98		EKS-DAR-00253	ENSDARG00000092403	BX324132.4
99		EKS-DAR-00238	ENSDARG00000092462	si:dkey-112g5.5
100		EKS-DAR-00149	ENSDARG00000092491	si:dkey-149i17.8
101		EKS-DAR-00287	ENSDARG00000092487	CH211-12E13.5-001; si:ch211-12e13.5
102		EKS-DAR-00162	ENSDARG00000055056	si:ch73-129a22.11
103		EKS-DAR-00227	ENSDARG00000092783	DKEY-33C12.9-001; si:dkey-33c12.9
104		EKS-DAR-00204	ENSDARG00000092701	LOC100534990; FP016063.1
105		EKS-DAR-00311	ENSDARG00000092740	si:ch211-57m13.7
106		EKS-DAR-00093	ENSDARG00000055129	zgc:113028; PIM3
107		EKS-DAR-00104	ENSDARG00000092627	BX649628.2
108		EKS-DAR-00260	ENSDARG00000092690	BX296549.3
109		EKS-DAR-00200	ENSDARG00000092198	DKEY-33C12.8-001; si:dkey-33c12.8
110		EKS-DAR-00304	ENSDARG00000055683	BX908796.1
111		EKS-DAR-00212	ENSDARG00000092101	si:dkey-84o3.15
112		EKS-DAR-00143	ENSDARG00000092079	BX470083.7
113		EKS-DAR-00250	ENSDARG00000092016	BX296549.2
114		EKS-DAR-00196	ENSDARG00000055453	AL953865.1; LOC566911
115		EKS-DAR-00203	ENSDARG00000092393	si:dkey-84o3.13
116		EKS-DAR-00222	ENSDARG00000092317	DKEY-265C15.9-001; si:dkey-265c15.9
117		EKS-DAR-00137	ENSDARG00000092339	dre-mir-2185-3
118		EKS-DAR-00129	ENSDARG00000055551	si:ch211-193e5.4
119		EKS-DAR-00151	ENSDARG00000055558	si:ch211-193e5.3
120		EKS-DAR-00198	ENSDARG00000092292	si:dkey-43b14.6
121		EKS-DAR-00178	ENSDARG00000092248	si:dkey-179a6.3; DKEY-179A6.3-001
122		EKS-DAR-00223	ENSDARG00000092253	zgc:162824; DKEY-265C15.8-001
123		EKS-DAR-00206	ENSDARG00000092231	si:dkey-84o3.9
124		EKS-DAR-00185	ENSDARG00000092234	si:dkey-179a6.2; DKEY-179A6.2-001
125		EKS-DAR-00236	ENSDARG00000092209	DKEY-19P15.6-001; zgc:162824
126		EKS-DAR-00216	ENSDARG00000095349	LOC793721; BX548044.13
127		EKS-DAR-00226	ENSDARG00000095352	si:dkey-84o3.14
128		EKS-DAR-00193	ENSDARG00000095338	si:ch211-214c11.3
129		EKS-DAR-00298	ENSDARG00000095386	si:ch211-151h10.1
130		EKS-DAR-00271	ENSDARG00000079459	si:ch211-122l14.5
131		EKS-DAR-00168	ENSDARG00000058663	CR848705.2
132		EKS-DAR-00263	ENSDARG00000095489	BX296549.5
133		EKS-DAR-00170	ENSDARG00000095461	CT826375.4
134		EKS-DAR-00150	ENSDARG00000095110	CR388046.4
135		EKS-DAR-00274	ENSDARG00000095109	LOC799315; BX571981.3
136		EKS-DAR-00328	ENSDARG00000095122	si:dkey-58b18.9
137		EKS-DAR-00115	ENSDARG00000095227	BX649628.3
138		EKS-DAR-00229	ENSDARG00000095723	BX548044.15; LOC793500
139		EKS-DAR-00270	ENSDARG00000095734	CH211-196G2.8-001; si:ch211-196g2.8
140		EKS-DAR-00118	ENSDARG00000095771	BX511311.11
141		EKS-DAR-00312	ENSDARG00000095853	si:ch211-57m13.3
142		EKS-DAR-00319	ENSDARG00000095884	si:ch211-57m13.9
143		EKS-DAR-00165	ENSDARG00000067762	CH211-207C6.8-001; si:ch211-207c6.8
144		EKS-DAR-00136	ENSDARG00000067767	BX510309.1
145		EKS-DAR-00268	ENSDARG00000095597	CR450805.4
146		EKS-DAR-00103	ENSDARG00000095537	BX927341.5
147		EKS-DAR-00228	ENSDARG00000095561	BX548044.14; LOC794008
148		EKS-DAR-00269	ENSDARG00000095525	si:ch211-126g16.3; si:ch211-126g16.1; CH211-126G16.1-001, CH211-126G16.3-001
149		EKS-DAR-00147	ENSDARG00000058477	si:ch211-222n4.5
150		EKS-DAR-00131	ENSDARG00000058386	BX323449.1
151		EKS-DAR-00167	ENSDARG00000074873	CT826375.2
152		EKS-DAR-00138	ENSDARG00000070424	CR381601.2
153		EKS-DAR-00101	ENSDARG00000087441	BX470083.3; LOC100330465
154		EKS-DAR-00308	ENSDARG00000079925	AL954695.2
155		EKS-DAR-00205	ENSDARG00000070134	BX469935.1
156		EKS-DAR-00239	ENSDARG00000016605	si:ch211-215m21.17
157		EKS-DAR-00183	ENSDARG00000087265	BX942819.2
158		EKS-DAR-00318	ENSDARG00000095027	si:dkey-31m5.3
159		EKS-DAR-00181	ENSDARG00000095044	si:ch211-196n4.2
160		EKS-DAR-00217	ENSDARG00000095054	LOC794306; BX548044.12
161		EKS-DAR-00187	ENSDARG00000095093	DKEY-236A14.4-001; si:dkey-236a14.4
162		EKS-DAR-00175	ENSDARG00000070015	DKEY-108D22.5-001; pcloa; si:dkey-108d22.5
163		EKS-DAR-00113	ENSDARG00000086403	CR381537.1
164		EKS-DAR-00288	ENSDARG00000075179	CR848663.1
165		EKS-DAR-00153	ENSDARG00000075243	BX914219.1
166		EKS-DAR-00278	ENSDARG00000075091	CU571064.1
167		EKS-DAR-00122	ENSDARG00000086312	CABZ01019032.1
168		EKS-DAR-00254	ENSDARG00000086350	si:ch211-126g16.3; OTTDARG00000026355
169		EKS-DAR-00124	ENSDARG00000091445	CU137681.8
170		EKS-DAR-00289	ENSDARG00000070692	si:dkey-80c24.1
171		EKS-DAR-00126	ENSDARG00000086727	CABZ01042513.2
172		EKS-DAR-00189	ENSDARG00000086763	CR677591.1
173		EKS-DAR-00327	ENSDARG00000070778	CR354611.1
174		EKS-DAR-00192	ENSDARG00000070740	CH211-196N4.3-001; si:ch211-196n4.3
175		EKS-DAR-00171	ENSDARG00000070741	si:ch211-214c11.9
176		EKS-DAR-00326	ENSDARG00000070731	CU467889.3
177		EKS-DAR-00117	ENSDARG00000091845	BX664705.1
178		EKS-DAR-00323	ENSDARG00000095902	si:ch211-57m13.10
179		EKS-DAR-00314	ENSDARG00000095953	si:ch211-57m13.6
180		EKS-DAR-00284	ENSDARG00000035646	si:ch211-12e13.6
181		EKS-DAR-00156	ENSDARG00000068686	CR388046.2
182		EKS-DAR-00255	ENSDARG00000068464	CR388046.1
183		EKS-DAR-00164	ENSDARG00000071058	si:ch211-270p4.3
184		EKS-DAR-00244	ENSDARG00000094014	si:ch211-165a10.4; si:ch211-165a10.2
185		EKS-DAR-00199	ENSDARG00000094047	zgc:162824
186		EKS-DAR-00188	ENSDARG00000017577	si:dkey-31m5.7
187		EKS-DAR-00313	ENSDARG00000094127	AL954695.5
188		EKS-DAR-00266	ENSDARG00000094168	CH211-126G16.5-001; si:ch211-126g16.5
189		EKS-DAR-00132	ENSDARG00000057284	DKEY-1P9.2-001; si:dkey-1p9.2
190		EKS-DAR-00099	ENSDARG00000094144	CU137681.9
191		EKS-DAR-00134	ENSDARG00000057265	si:dkey-1p9.2; DKEY-236A14.11-001; si:dkey-236a14.11
192		EKS-DAR-00247	ENSDARG00000057253	si:dkey-236a14.13
193		EKS-DAR-00279	ENSDARG00000094226	BX470188.1
194		EKS-DAR-00241	ENSDARG00000094348	CR848663.2
195		EKS-DAR-00173	ENSDARG00000094339	si:ch211-196n4.1
196		EKS-DAR-00214	ENSDARG00000068817	LOC793289; BX548044.2
197		EKS-DAR-00267	ENSDARG00000068809	BX324132.1
198		EKS-DAR-00264	ENSDARG00000094552	CR450805.3
199		EKS-DAR-00097	ENSDARG00000094539	BX511311.10
200		EKS-DAR-00180	ENSDARG00000088095	FP016238.1; LOC100329704
201		EKS-DAR-00144	ENSDARG00000088058	BX119909.1
202		EKS-DAR-00275	ENSDARG00000088067	CH211-196G2.7-001; si:ch211-196g2.7
203		EKS-DAR-00258	ENSDARG00000071695	CT956093.2
204		EKS-DAR-00127	ENSDARG00000071880	BX323449.3
205		EKS-DAR-00315	ENSDARG00000032975	BX629350.1
206		EKS-DAR-00135	ENSDARG00000071745	CR456631.1
207		EKS-DAR-00296	ENSDARG00000088502	CU694807.1
208		EKS-DAR-00119	ENSDARG00000088369	BX511311.5
209		EKS-DAR-00146	ENSDARG00000071183	si:ch73-272h16.1
210		EKS-DAR-00300	ENSDARG00000075780	si:ch211-57m13.5
211		EKS-DAR-00316	ENSDARG00000052935	BX629350.2; LOC566055
212		EKS-DAR-00177	ENSDARG00000088583	BX649415.3
213		EKS-DAR-00139	ENSDARG00000088602	CABZ01063868.1
214		EKS-DAR-00110	ENSDARG00000088626	BX927341.2
215		EKS-DAR-00109	ENSDARG00000087539	AL953848.1
216		EKS-DAR-00306	ENSDARG00000076517	AL929185.1; LOC100332036
217		EKS-DAR-00148	ENSDARG00000053731	AL954695.1
218		EKS-DAR-00281	ENSDARG00000053340	si:ch211-138g9.3
219		EKS-DAR-00155	ENSDARG00000094751	CR450827.4
220		EKS-DAR-00251	ENSDARG00000094756	si:dkey-58b18.10; si:dkey-58b18.4; si:dkey-58b18.7
221		EKS-DAR-00302	ENSDARG00000041550	si:dkey-14a7.2
222		EKS-DAR-00242	ENSDARG00000090229	CT583626.4
223		EKS-DAR-00191	ENSDARG00000090355	si:dkey-40j3.1
224		EKS-DAR-00172	ENSDARG00000094999	si:ch211-254p10.3
225		EKS-DAR-00321	ENSDARG00000094927	si:dkey-93l1.4
226		EKS-DAR-00098	ENSDARG00000090413	BX470083.5
227		EKS-DAR-00161	ENSDARG00000090604	si:ch211-126g16.4
228		EKS-DAR-00140	ENSDARG00000090609	CABZ01086642.1
229		EKS-DAR-00116	ENSDARG00000090613	CABZ01042513.3
230		EKS-DAR-00186	ENSDARG00000041462	BX323876.1
231		EKS-DAR-00221	ENSDARG00000094866	si:dkey-33c12.5; DKEY-33C12.5-001
232		EKS-DAR-00324	ENSDARG00000094885	si:dkey-40h17.6
233		EKS-DAR-00273	ENSDARG00000068190	CH211-119D14.4-001; si:ch211-119d14.4
234		EKS-DAR-00197	ENSDARG00000068145	BX323876.4
235		EKS-DAR-00160	ENSDARG00000090994	CABZ01086639.4
236		EKS-DAR-00282	ENSDARG00000041823	AL845435.1; OTTDARG00000027205
237		EKS-DAR-00130	ENSDARG00000057769	si:dkey-10f21.3