※ PIM family introduction

    PIM consists of three members, PIM-1, PIM-2 and PIM-3. Sequence analysis show that PIM-1 and PIM-2 share a sequence identical of 61%, PIM-1 and PIM-3 are 77% identical. PIM kinases play an important role in cancer. PIM-1 and PIM-2 transgenic mice overexpression these genes have been observed to develop lymphomas. In addition, PIM-1 is over expressed in c-myc transgene driven prostate tumors in mice. In human, PIM-1 and PIM-2 are involved in prostate cancer development. Studies show that PIM-3 is over expressed in colorectal, pancreatic and hepatocellular carcinoma. The mechanisms that PIMs implicated in cancer have been reported that PIMs act as key regulator in several major proliferative and survival signaling pathways or influence the activity of specific cell cycle molecules and changes in gene expression (1).

Reference
1. Isaac, M., Siu, A. and Jongstra, J. (2011) The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms. Drug Resist Updat, 14, 203-211. PMID: 21601509

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAG-00084	ENSTGUG00000016503
2		EKS-TAG-00094	ENSTGUG00000016445
3		EKS-TAG-00103	ENSTGUG00000016467
4		EKS-TAG-00111	ENSTGUG00000016468
5		EKS-TAG-00068	ENSTGUG00000016485
6		EKS-TAG-00081	ENSTGUG00000016626
7		EKS-TAG-00077	ENSTGUG00000016198
8		EKS-TAG-00100	ENSTGUG00000016151
9		EKS-TAG-00098	ENSTGUG00000004886
10		EKS-TAG-00072	ENSTGUG00000016751
11		EKS-TAG-00076	ENSTGUG00000016725
12		EKS-TAG-00106	ENSTGUG00000016845
13		EKS-TAG-00067	ENSTGUG00000015232
14		EKS-TAG-00079	ENSTGUG00000015140
15		EKS-TAG-00105	ENSTGUG00000015196
16		EKS-TAG-00073	ENSTGUG00000015242
17		EKS-TAG-00097	ENSTGUG00000015282
18		EKS-TAG-00095	ENSTGUG00000015296
19		EKS-TAG-00102	ENSTGUG00000015047
20		EKS-TAG-00096	ENSTGUG00000003363
21		EKS-TAG-00091	ENSTGUG00000015813
22		EKS-TAG-00087	ENSTGUG00000015970
23		EKS-TAG-00088	ENSTGUG00000015977
24		EKS-TAG-00066	ENSTGUG00000003897	PIM3
25		EKS-TAG-00092	ENSTGUG00000015583
26		EKS-TAG-00070	ENSTGUG00000015552
27		EKS-TAG-00080	ENSTGUG00000014338
28		EKS-TAG-00074	ENSTGUG00000014454
29		EKS-TAG-00085	ENSTGUG00000014408
30		EKS-TAG-00086	ENSTGUG00000014394
31		EKS-TAG-00112	ENSTGUG00000014587
32		EKS-TAG-00090	ENSTGUG00000014652
33		EKS-TAG-00082	ENSTGUG00000014682
34		EKS-TAG-00108	ENSTGUG00000014699
35		EKS-TAG-00104	ENSTGUG00000014882
36		EKS-TAG-00078	ENSTGUG00000014802
37		EKS-TAG-00071	ENSTGUG00000013726
38		EKS-TAG-00083	ENSTGUG00000013728
39		EKS-TAG-00101	ENSTGUG00000013703
40		EKS-TAG-00093	ENSTGUG00000013680
41		EKS-TAG-00099	ENSTGUG00000013802
42		EKS-TAG-00107	ENSTGUG00000013807
43		EKS-TAG-00089	ENSTGUG00000017234
44		EKS-TAG-00109	ENSTGUG00000017212
45		EKS-TAG-00075	ENSTGUG00000017104
46		EKS-TAG-00069	ENSTGUG00000017083
47		EKS-TAG-00113	ENSTGUG00000000954	PIM1
48		EKS-TAG-00110	ENSTGUG00000000507