Drosophila melanogaster CAMK PKD※ PKD family introduction PKD belong to CAMK family. PKD contains three genes in mammals, known as, PKD1, PKD2 and PKD3. Sequence analysis show that PKDs contain two DAG-type domains (C1 and C2 domain), and followed by a PH domain and C-terminal protein kinase catalytic domain. Activated PKC recruits PKD through C1 domain and cause the PKD activation loop phosphorylation which induce a conformational change that catalytic activity to maximum. PKDs act as key regulator involved in a variety of cell physiology, including cell survival after oxidative stress, inhibition of cell migration, gene transcription and golgi-vesicle fission and transport (1).
Reference
1. Fu, Y. and Rubin, C.S. (2011) Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology. EMBO Rep, 12, 785-796. PMID: 21738220
There are 1 genes. Reviewed (0)
or Unreviewed (1) 
1. Fu, Y. and Rubin, C.S. (2011) Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology. EMBO Rep, 12, 785-796. PMID: 21738220
There are 1 genes. Reviewed (0)
or Unreviewed (1) | No. | Status | EKPD ID | Gene ID | Gene Name |
|---|---|---|---|---|
| 1 | |