※ TSSK family introduction

    TSSK (testis-specific serine kinase) belong to CAMK family. Six members have been identified in this family in human genome, however, only five possess kinase catalytic domain, including TSSK1, TSSK2, TSSK3, TSSK4 and TSSK6. TSSKs contain a kinase domain and a variable short C-terminal extension. All members contain a conserved activation loop threonine phosphorylation site. Two members TSSK2 and TSSK3 can undergo autophosphorylation.TSSK1 and TSSK2 are formed by tandem duplication and a dual knockout is infertile as a heterozygote. TSSK3 is expressed only in interstitial Leydig cells, which contrasts with the expression of TSSK1 and TSSK2 in late spermatids and sperm. TSSK4 can bind to CREB by Y2H and can phosphorylate and activate CREB in human and mouse cells (1).

Reference
1. Wikinome Annotation:    Kinase Family TSSK

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CII-00043	ENSCING00000018189	LOC100178132; CIN.49870
2		EKS-CII-00049	ENSCING00000018308
3		EKS-CII-00047	ENSCING00000022812	LOC100182986
4		EKS-CII-00050	ENSCING00000002645	CIN.13507; LOC100175360
5		EKS-CII-00044	ENSCING00000023798	CIN.16415; LOC100185582
6		EKS-CII-00046	ENSCING00000009229	LOC100182063; CIN.37521
7		EKS-CII-00045	ENSCING00000012478	LOC100180320; CIN.18846
8		EKS-CII-00048	ENSCING00000024758	LOC100176180; CIN.18870