※ Trbl family introduction

    Trbl belong to CAMK family. Three genes encoding trbl have been identified in mammals, and the related orthologus also been found in vertebrates and invertebrates. The Trbl kinases share a conserved central kinase catalytic domain flanked by not unclosely related N-terminal and C-terminal sequences. However, the kinase domains lack the key active site lysine and might be an inactive kinase. Studies show that Trbl kinases are key molecule function on controlling Mitogen-activated protein kinase cascades. For instance, human trbl-1 overexpression can modulate the activation of Ras/MEK-1/ERK pathway, and some MAPKK interacts with Trbls which results enhance of kinase activation (1).

Reference
1. Kiss-Toth, E., Bagstaff, S.M., Sung, H.Y., Jozsa, V., Dempsey, C., Caunt, J.C., Oxley, K.M., Wyllie, D.H., Polgar, T., Harte, M. et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem, 279, 42703-42708. PMID: 15299019

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00039	ENSLAFG00000006965	TRIB3
2		EKS-LOA-00038	ENSLAFG00000012712	TRIB1
3		EKS-LOA-00037	ENSLAFG00000013795	TRIB2