※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRD-01084	BRADI1G05950	BRADI1G05950
2		EKS-BRD-01086	BRADI1G05930	BRADI1G05930
3		EKS-BRD-01083	BRADI2G33037	BRADI2G33037
4		EKS-BRD-01078	BRADI3G28720	BRADI3G28720
5		EKS-BRD-01082	BRADI2G49590	BRADI2G49590
6		EKS-BRD-01075	BRADI3G49100	BRADI3G49100
7		EKS-BRD-01081	BRADI2G06060	BRADI2G06060
8		EKS-BRD-01080	BRADI2G07790	BRADI2G07790
9		EKS-BRD-01085	BRADI1G56100	BRADI1G56100
10		EKS-BRD-01079	BRADI3G10320	BRADI3G10320
11		EKS-BRD-01074	BRADI2G47850	BRADI2G47850
12		EKS-BRD-01077	BRADI3G54860	BRADI3G54860
13		EKS-BRD-01076	BRADI2G14310	BRADI2G14310