※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00449	ENSMODG00000018728	CSNK1E
2		EKS-MOD-00442	ENSMODG00000009937
3		EKS-MOD-00446	ENSMODG00000019254	LOC100619142
4		EKS-MOD-00447	ENSMODG00000010802	CSNK1G1
5		EKS-MOD-00443	ENSMODG00000003587	CSNK1D
6		EKS-MOD-00448	ENSMODG00000024914
7		EKS-MOD-00444	ENSMODG00000025184	LOC100618000
8		EKS-MOD-00441	ENSMODG00000025188	LOC100023040
9		EKS-MOD-00445	ENSMODG00000004527	CSNK1G2
10		EKS-MOD-00440	ENSMODG00000025404	CSNK1A1