※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (11) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORB-01053	OB01G16320	OB01G16320
2		EKS-ORB-01051	OB02G20900	OB02G20900
3		EKS-ORB-01046	OB01G37360	OB01G37360
4		EKS-ORB-01048	OB05G35510	OB05G35510
5		EKS-ORB-01049	OB10G20380	OB10G20380
6		EKS-ORB-01047	OB02G31900	OB02G31900
7		EKS-ORB-01052	OB01G18500	OB01G18500
8		EKS-ORB-01054	OB03G43950	OB03G43950
9		EKS-ORB-01050	OB04G25740	OB04G25740
10		EKS-ORB-01056	OB01G39510	OB01G39510
11		EKS-ORB-01055	OB01G41500	OB01G41500