※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORL-00526	ENSORLG00000001536	CSNK1G1
2		EKS-ORL-00523	ENSORLG00000017244	CSNK1D
3		EKS-ORL-00521	ENSORLG00000020637	CSNK1A1; Ola.5309
4		EKS-ORL-00525	ENSORLG00000008960	CSNK1G2 (1 of 2); CSNK1G2 (2 of 2)
5		EKS-ORL-00524	ENSORLG00000007876	CSNK1G2 (1 of 2); CSNK1G2 (2 of 2)
6		EKS-ORL-00522	ENSORLG00000014454	CSNK1E (1 of 2)