※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PAT-00428	ENSPTRG00000014365	CSNK1E; ENSG00000213923
2		EKS-PAT-00429	ENSPTRG00000005793	CSNK1A1; ENSG00000180138
3		EKS-PAT-00432	ENSPTRG00000010218	CSNK1G2; ENSG00000133275
4		EKS-PAT-00427	ENSPTRG00000009796	ENSG00000141551; CSNK1D
5		EKS-PAT-00426	ENSPTRG00000017401	CSNK1A1; ENSG00000113712
6		EKS-PAT-00431	ENSPTRG00000017182	CSNK1G3; ENSG00000151292
7		EKS-PAT-00430	ENSPTRG00000007157	CSNK1G1; ENSG00000169118