※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (9) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PHP-00699	PP1S66_174V6	A9SCV1_PHYPA; PHYPADRAFT_210931
2		EKS-PHP-00696	PP1S151_38V6
3		EKS-PHP-00700	PP1S131_16V6	PHYPADRAFT_166955; A9SX02_PHYPA
4		EKS-PHP-00698	PP1S114_178V6
5		EKS-PHP-00693	PP1S430_12V6	A9U233_PHYPA; PHYPADRAFT_154549
6		EKS-PHP-00695	PP1S182_90V6	A9T8B5_PHYPA; PHYPADRAFT_141747
7		EKS-PHP-00694	PP1S182_82V6	A9T8A9_PHYPA; PHYPADRAFT_141762
8		EKS-PHP-00697	PP1S216_7V6	PHYPADRAFT_60088; A9TEV1_PHYPA
9		EKS-PHP-00701	PP1S208_44V6