※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-POT-01704	POPTR_0006s15000	POPTRDRAFT_831950
2		EKS-POT-01707	POPTR_0010s08110	XM_002314444.1
3		EKS-POT-01705	POPTR_0002s03730	POPTRDRAFT_816074
4		EKS-POT-01701	POPTR_0018s07090	POPTRDRAFT_929346
5		EKS-POT-01702	POPTR_0001s20450	POPTRDRAFT_827589
6		EKS-POT-01713	POPTR_0018s08230	POPTRDRAFT_736966
7		EKS-POT-01708	POPTR_0008s16790	POPTRDRAFT_803757
8		EKS-POT-01703	POPTR_0003s04170
9		EKS-POT-01710	POPTR_0018s09140	POPTRDRAFT_835886
10		EKS-POT-01711	POPTR_0006s25640	POPTRDRAFT_819545
11		EKS-POT-01709	POPTR_0013s04430	POPTRDRAFT_893031
12		EKS-POT-01706	POPTR_0005s24860	POPTRDRAFT_651930
13		EKS-POT-01712	POPTR_0018s00420	POPTRDRAFT_260677