※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SAH-00421	ENSSHAG00000007288
2		EKS-SAH-00423	ENSSHAG00000007638	CSNK1D
3		EKS-SAH-00426	ENSSHAG00000018581	CSNK1G1
4		EKS-SAH-00417	ENSSHAG00000001072
5		EKS-SAH-00425	ENSSHAG00000004621	CSNK1E
6		EKS-SAH-00424	ENSSHAG00000011182
7		EKS-SAH-00418	ENSSHAG00000011680
8		EKS-SAH-00420	ENSSHAG00000006727	CSNK1G2
9		EKS-SAH-00419	ENSSHAG00000011884
10		EKS-SAH-00422	ENSSHAG00000015356	CSNK1A1L