※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-00962	SELMODRAFT_231975	SELMODRAFT_231975
2		EKS-SEM-00965	SELMODRAFT_113824	SELMODRAFT_113824
3		EKS-SEM-00964	SELMODRAFT_116791	SELMODRAFT_116791
4		EKS-SEM-00970	SELMODRAFT_269002	SELMODRAFT_269002
5		EKS-SEM-00971	SELMODRAFT_177864	SELMODRAFT_177864
6		EKS-SEM-00969	SELMODRAFT_144765	SELMODRAFT_144765
7		EKS-SEM-00967	SELMODRAFT_235810	SELMODRAFT_235810
8		EKS-SEM-00968	SELMODRAFT_139482	SELMODRAFT_139482
9		EKS-SEM-00966	SELMODRAFT_81432	SELMODRAFT_81432
10		EKS-SEM-00963	SELMODRAFT_127114	SELMODRAFT_127114