※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEI-01212	Si017146m.g	Si017146m.g
2		EKS-SEI-01215	Si010067m.g	Si010067m.g
3		EKS-SEI-01224	Si000515m.g	Si000515m.g
4		EKS-SEI-01221	Si021536m.g	Si021536m.g
5		EKS-SEI-01218	Si001531m.g	Si001531m.g
6		EKS-SEI-01217	Si035447m.g	Si035447m.g
7		EKS-SEI-01216	Si021938m.g	Si021938m.g
8		EKS-SEI-01219	Si017326m.g	Si017326m.g
9		EKS-SEI-01213	Si001321m.g	Si001321m.g
10		EKS-SEI-01222	Si000563m.g	Si000563m.g
11		EKS-SEI-01223	Si034472m.g	Si034472m.g
12		EKS-SEI-01220	Si021518m.g	Si021518m.g
13		EKS-SEI-01214	Si017120m.g	Si017120m.g
14		EKS-SEI-01211	Si001311m.g	Si001311m.g