※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (11) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOT-01044	PGSC0003DMG400010312	PGSC0003DMG400010312
2		EKS-SOT-01047	PGSC0003DMG400009606	PGSC0003DMG400009606
3		EKS-SOT-01048	PGSC0003DMG400029394	PGSC0003DMG400029394
4		EKS-SOT-01045	PGSC0003DMG400020075	PGSC0003DMG400020075
5		EKS-SOT-01041	PGSC0003DMG400032791	PGSC0003DMG400032791
6		EKS-SOT-01049	PGSC0003DMG400018580	PGSC0003DMG400018580
7		EKS-SOT-01050	PGSC0003DMG400032142	PGSC0003DMG400032142
8		EKS-SOT-01040	PGSC0003DMG400002577	PGSC0003DMG400002577
9		EKS-SOT-01042	PGSC0003DMG402025508	PGSC0003DMG402025508
10		EKS-SOT-01046	PGSC0003DMG400000372	PGSC0003DMG400000372
11		EKS-SOT-01043	PGSC0003DMG400004854	PGSC0003DMG400004854