※ CK1 family introduction

    CK1 (Casein kinase I) are characterized by its ser/thr protein kinase catalytic activity on phoshorylation of casein in vitro in a cycle AMP-independent manner. Six isoforms and CK1-like kinase have been identified in this family. Sequence analysis show that all members share a N-terminal conserved kinase catalytic domain and a variable C-terminal sequence. Several potential regulatory mechanisms for CK1s have been described, including activation via phosphorylation of PKA, 14-3-3 binding and autoinhibition. CK1s are involved in a variety of cellular processes via phosphorylation of a large range of substrates, for instance, stabilize AIB1 and increase Erα transcriptional activity, facilitate CK1α/FADD/CaM complex assembly for proper cell cycle progression, reduces DNA-binding activity of Dnmt1, blocks nuclear export and so on. (1)

Reference
1. Cheong, J.K. and Virshup, D.M. (2011) Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol, 43, 465-469. PMID: 21145983

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOB-01118	Sb09g030690	SB09G030690; SORBIDRAFT_09g030690; Sb09g030690
2		EKS-SOB-01127	Sb03g036000
3		EKS-SOB-01126	Sb08g023280
4		EKS-SOB-01122	Sb04g010990	SORBIDRAFT_04g010990; Sb04g010990; SB04G010990
5		EKS-SOB-01121	Sb03g025700	SORBIDRAFT_03g025700; SB03G025700; Sb03g025700
6		EKS-SOB-01116	Sb03g032560	SB03G032560; SORBIDRAFT_03g032560; Sb03g032560
7		EKS-SOB-01119	Sb04g026400	Sb04g026400; SORBIDRAFT_04g026400; SB04G026400
8		EKS-SOB-01123	Sb03g000820
9		EKS-SOB-01125	Sb09g006270	SB09G006270; SORBIDRAFT_09g006270; Sb09g006270
10		EKS-SOB-01128	Sb01g005460	SB01G005460; Sb01g005460; SORBIDRAFT_01g005460
11		EKS-SOB-01117	Sb06g022560
12		EKS-SOB-01120	Sb01g019390	SORBIDRAFT_01g019390; Sb01g019390; SB01G019390
13		EKS-SOB-01124	Sb04g036670	SORBIDRAFT_04g036670; Sb04g036670; SB04G036670