※ TTBK family introduction

    TTBKs belong to CK1 family, and two genes encoding the kinase have been identified which are known as TTBK1 and TTBK2. TTBKs were first described as microtubule-associated proteins (MAPs) which can directly phosphorylate both tubulin and tau at multiple sites. Studies also show that TTBK1 is a neuron-specific kinase that can mediate the phosphorylation of tau and aggreagtion at Alzhieimer's disease related sites. Abnormal expressions of TTBK2 have been reported to contribute ti spinocerebellar ataxia type 11 (1).

Reference
1. Qi, H., Yao, C., Cai, W., Girton, J., Johansen, K.M. and Johansen, J. (2009) Asator, a tau-tubulin kinase homolog in Drosophila localizes to the mitotic spindle. Dev Dyn, 238, 3248-3256. PMID: 19890914

  Reviewed (0)  or Unreviewed (4) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00128	ENSTNIG00000005066	TTBK1
2		EKS-TEN-00130	ENSTNIG00000017260	TTBK2 (1 of 3); GSTENG00032072001
3		EKS-TEN-00129	ENSTNIG00000019265	TTBK2 (2 of 3)
4		EKS-TEN-00131	ENSTNIG00000003667	GSTENG00005670001; TTBK2 (3 of 3)