※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ART-00572	AT2G40120	T07M07.1; At2g40120; AT2G40120
2		EKS-ART-00568	AT5G35980	At5g35980At5g35990; YAK1; AT5G35980; At5g35980
3		EKS-ART-00575	AT3G17750	AT3G17750; At3g17750
4		EKS-ART-00571	AT3G25840	AT3G25840; At3g25840
5		EKS-ART-00574	AT1G73460	At1g73460; AT1G73460
6		EKS-ART-00573	AT1G73450	T9L24.35; At1g73460; AT1G73450
7		EKS-ART-00569	AT1G13350	AT1G13350; At1g13350
8		EKS-ART-00570	AT3G53640	F4P12_340; AT3G53640; At3g53640
9		EKS-ART-00576	AT4G03175	At4g03175; AT4G03175