※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRR-00878	Bra039487	Bra039487
2		EKS-BRR-00884	Bra003844	Bra003844
3		EKS-BRR-00883	Bra015990	Bra015990
4		EKS-BRR-00881	Bra017346	Bra017346
5		EKS-BRR-00886	Bra017026	Bra017026
6		EKS-BRR-00882	Bra004984	Bra004984
7		EKS-BRR-00879	Bra035364	Bra035364
8		EKS-BRR-00880	Bra025165	Bra025165
9		EKS-BRR-00885	Bra022240	Bra022240